Science Webinar Series

Webinar | Deciphering cancer: Genomic instability in cancer

See allHide authors and affiliations

Science  11 Nov 2016:
Vol. 354, Issue 6313, pp. 775
DOI: 10.1126/science.354.6313.775-b

Summary

While it is well established that DNA damage can increase the risk of cancer, changes to the epigenome or the chromatin architecture are equally important. DNA damage triggers a redistribution of DNA-binding proteins around the site of damage, resulting in localized and temporary alteration of chromatin structure. However, repeated cycles of DNA damage and repair may lead to permanent changes in the epigenome, thereby promoting the onset of pathological diseases such as cancer. This webinar will examine how we may be able to develop effective new therapeutic options for cancer treatment by targeting proteins responsible for chromatin modifications.