Research Articles

RNA interference is essential for cellular quiescence

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Science  11 Nov 2016:
Vol. 354, Issue 6313, aah5651
DOI: 10.1126/science.aah5651

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RNAi soothes the path to quiescence

Cells, such as those in stem cell niches and immunity memory cells, can exist in a nondividing, quiescent state, from which they can be aroused with the appropriate signal. RNA interference (RNAi) is an important epigenetic pathway in many organisms. Roche et al. found that in fission yeast, RNAi was an essential regulator of the quiescent state. RNAi promoted proper chromosome segregation during entry into quiescence. It also prevented inappropriate silencing of the ribosomal DNA during quiescence.

Science, this issue p. 10.1126/science.aah5651