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Science  25 Nov 2016:
Vol. 354, Issue 6315, pp. 1055
DOI: 10.1126/science.354.6315.1055-a

Live-Cell Metabolic Assay Platform

The Agilent Seahorse XFp Analyzer measures metabolic functions of live cells with same-day results. From routine analysis to cutting-edge research, it enables researchers to rapidly assess both mitochondrial respiration and glycolysis in live cells, generate metabolic phenotypes of precious samples (as few as 15,000 cells per condition), and conduct functional metabolic assays without the need for special bioenergetics expertise. Seahorse XF test kits and reagents simplify cellular bioenergetics by providing precalibrated, pretested reagents for metabolic phenotyping, mitochondrial respiration, glycolysis, and fatty-acid oxidation in cells. Because Seahorse XF measurements are nondestructive, the metabolic rate of the same cell population can be measured repeatedly while up to four different drugs are injected sequentially into each well. Total assay time is typically 60 minutes to 90 minutes. To maintain normal cell physiology, a temperature control system maintains the cellular environment at 37°C (or another preset temperature).

Single-Cell Analysis

The ICELL8 Single-Cell System can isolate thousands of single cells and process specific cells for analysis, including NGS. It also includes an imaging station and CellSelect software, which images each nanowell and provides automatic selection of single cells for downstream processing. ICELL8 can isolate up to 1,800 single cells, ranging from 5 μm–100 μm in size on a single chip, including cells from solid tumors, brain cells, pulmonary airway cells, and multiple cell lines. The SmartChip platform can be used for profiling and validating molecular biomarkers, and can perform massively parallel singleplex PCR for one-step target enrichment as well as library preparation for clinical NGS. The Apollo 324 library preparation system can be used to process DNA and RNA from clinical samples to NGS-ready libraries. These technologies offer a powerful set of tools for biological analysis at the molecular and single-cell level in the life sciences, pharmaceutical, and clinical laboratory industries.

Manual Colony Counter

The aCOLade 2 manual colony counter with automatic count recording is an ideal choice for budget-conscious microbiology laboratories. It consists of an illuminated receiver plate and a large LED display. The pressure of marking a colony with a felt-tip pen registers a cumulative count on the digital display with confirmation by an audible tone (that can be turned on or off). A built-in averaging facility calculates the average count over multiple plates. Counting results, as well as useful statistics such as standard deviation, can be sent to the accessory printer or to a computer via the supplied USB cable. Substage illumination by low-energy bright LEDs allows glare-free optimum viewing. A switchable black background is provided to enhance viewing of translucent and difficult-to-see colonies. Two Wolfhuegel graticules and dish-centering adapters facilitate use with 50 mm–90 mm dishes. A choice of magnifiers and a printer are available as optional accessories.

Microplate Stacker

The patented BioStack 4 Microplate Stacker from BioTek Instruments features unique automatic microplate delidding and relidding technology, which is especially useful in cell-based assay workflows. The BioStack 4 facilitates increased throughput and greater productivity in processes involving lidded and unlidded 96-, 384-, and 1,536-well microplates, as well as select 6- to 48-well microplates. Its design incorporates a two-position carrier for ultrafast transfer times, and its small overall footprint allows operation in biosafety cabinets. A rotational gripper enhances versatility in portrait or landscape orientation, while the unique lid-gripping method minimizes exposure of the microplate's contents during transfer. Finally, interchangeable plate storage stacks are available for the throughput needs of up to 30 lidded or 50 unlidded microplates, with automated restacking. Many of BioTek's imagers, readers, washers, and dispensers may be integrated with the BioStack 4, which is directly controlled via the respective instrument's integrated software.

Fluorescence Cell Analyzer

The Countstar Fluorescence Cell Analyzer can do all that a traditional flow cytometer does but faster, easier, and at much lower cost. A compact, benchtop unit featuring an integral processor and display screen, the Countstar has a number of advantages over conventional systems. First, it is very easy to operate due to its high level of automation, which makes training very simple—so researchers can quickly start to create results. Second, it is always ready to use—there are no set times or preparation periods needed. Third, it is significantly less expensive to purchase and run than any of the traditional flow cytometry systems. A standard system could take up to 165 minutes to process 15 samples, while the Countstar can do the same job in 50 minutes.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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