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Science  02 Dec 2016:
Vol. 354, Issue 6316, pp. 1174
DOI: 10.1126/science.354.6316.1174-a

β-Glucuronidase Removal Kit

β-Gone sorbent delivers fast, one-step β-glucuronidase removal from hydrolyzed urine. Analysts in forensic toxicology and clinical testing labs have wrestled for years to find a solution that is rapid yet sensitive when working with hydrolyzed urine samples. Within the body, a glucuronidation reaction during metabolism promotes the elimination of drugs through urine. To accurately analyze drug metabolites, the glucuronide must be cleaved, typically with hydrolysis using an enzyme. Hydrolysis with β-glucuronidase produces a urine sample with a significant amount of solubilized enzyme that must be removed before HPLC analysis. If the enzymes are not removed from the sample, they can build up on the HPLC column, reducing its lifetime. β-Gone also offers a better alternative to the "dilute-and-shoot" method in which sensitivity and accuracy are compromised when the sample is diluted. It also improves assay performance and column lifetime, and reduces mass spectrometer maintenance.

High-Throughput Evaporator

The Series 3 HT evaporator range represents the ultimate in solvent removal technology. Incorporating a high-performance vacuum pump, the latest touchscreen technology, and a sleek ergonomic design, the Series 3 HT evaporator optimizes evaporation processes and makes them effortless. Available in 6- and 12-sample holder configurations, these evaporators are the system of choice for high-throughput (HT) sample drying, offering high capacity, unique technology that eliminates cross contamination due to sample bumping, and automated temperature and pressure monitoring to prevent sample degradation. Intuitive touchscreen controls enhance monitoring and review of the whole evaporation process. For popular solvent removal protocols, preset "press and go" methods make operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex multistage evaporation methods can be set up and run quickly and easily.

Biomanufacturing Platform

ProteoNic's CHOGUN expression vector is included alongside Horizon's HD-BIOP3 GS Null CHO cell line, providing a complete biomanufacturing platform. Biomanufacturing in Chinese hamster ovary (CHO) cells is performed based on high-expressing clones, the identification of which can be streamlined through metabolic selection. The only source of glutamine production in the cell is through the enzyme glutamine synthetase (GS). Methionine sulfoximine (MSX) inhibits GS activity in cells so that only those clones that are most efficient at producing recombinant protein are able to proliferate. However, MSX is toxic. An alternative approach is to use a cell line that lacks GS (GS Null). When the gene for a biotherapeutic product is provided on a vector alongside GS, such as in the CHOGUN vector, production of GS is linked to the production of the protein of interest, so cells that survive selection are more likely to be expressing the product at high levels.

Zika Virus Recombinant Antigens and Antibodies

Recombinant antigens and antibodies for Zika virus (ZIKV) are available for the development of rapid assays, and will aid researchers to overcome the problem of cross-reactivity with related viruses. ZIKV is causing worldwide concern because of its connection to a neurological birth disorder and its rapid spread. The virus is closely related to other mosquito-borne flaviviruses. PCR assays and antibody (IgM/IgG) detection assays have difficulty in differentiating between mosquito-borne flaviviruses, and only detect infections up to five days after the onset of symptoms. Recombinant antigens of envelope and NS1 proteins can overcome the problem of flavivirus cross-reactivity with the closely related dengue, yellow fever, Japanese encephalitis, and West Nile viruses in diagnostics. The recombinant proteins are produced in Sf9 insect cells and have been tested to work in lateral-flow formats. These antigens are available in 1-mg size for evaluation, and in gram-bulk quantiies for the development of diagnostic assays.

Triple Quadrupole GC/MS

Laboratories that test the safety of our food and water are turning to triple quadrupole GC/MS systems because their selectivity enables them to better handle complex matrices than standard single quadrupole systems. Agilent's 7000D and 7010B include enhancements that not only improve analytical performance but make them easier to use than any previous triple quad GC/MS system. Those who want to run samples on their triple quad can open existing single quad GC/MS methods with a single mouse click using Agilent MassHunter software. This capability also streamlines the transition from single-ion monitoring on the single quad to tandem mass spectrometry (MS/MS) on the triple quad. The 7010B includes Agilent's exclusive high-efficiency ion source, which enhances the instrument's sensitivity by a factor of 10. Both models are also available with Agilent's patented JetClean self-cleaning ion source, which readily removes matrix deposits that can build up over time and compromise instrument performance.

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