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mRNA quality control

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Science  09 Dec 2016:
Vol. 354, Issue 6317, pp. 1246
DOI: 10.1126/science.354.6317.1246-b

DNA is packaged into chromatin, and it must be actively unpacked, or remodeled, for genes to be transcribed into mRNA. That mRNA, synthesized in the nucleus, is also packed onto proteins, forming mRNA ribonucleoparticles (mRNPs). mRNPs are then shunted into the cytoplasm. Babour et al. show that one of the chromatin remodeling machines, the enzyme complex ISW1, has a second role in checking that mRNPs are properly packaged and competent to be exported to the cytoplasm. The ISW1 complex binds directly to the premature mRNPs, retaining them in proximity to their transcription sites.

Cell 167, 1201 (2016).

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