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Comment on “Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2”

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Science  23 Dec 2016:
Vol. 354, Issue 6319, pp. 1543
DOI: 10.1126/science.aaf6236

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Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum. This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

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