ReportVascular Disease

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

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Science  24 Feb 2017:
Vol. 355, Issue 6327, pp. 842-847
DOI: 10.1126/science.aag1381

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  • RE: Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
    • Fei Luo, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University
    • Other Contributors:
      • Yuan Guo, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University
      • Xiangping Li, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University

    We have greatly enjoyed reading the recently published article by Fuster and colleagues (1). They found that TET2 acted as a negative transcriptional regulator of proinflammatory responses and TET2 deficiency accelerated atherosclerosis development. Li et al. (2) demonstrated that down-regulation of TET2 inhibited macrophage autophagy. Moreover, inhibition of autophagy was reported to decrease cholesterol efflux in macrophages (3, 4). Therefore, TET2 deficiency may decrease cholesterol efflux from macrophages via inhibiting autophagy. As we known, the reduction in cholesterol efflux results in abnormal accumulation of cholesterol in macrophages, which could lead to the increased proinflammatory responses and atherosclerosis (5). This article found that TET2 deficiency did not affect cholesterol trafficking regulators of bone-marrow-derived or peritoneal macrophages, however bone-marrow-derived or peritoneal macrophages were really different from macrophages in atherosclerotic plaques, which were always cholesterol loaded. They may briefly discuss cholesterol efflux capacity and cholesterol trafficking regulators of TET2-deficient macrophages after cholesterol loaded. Besides, there is a mistake in Fig. 3C, the right picture should be “10% KO BMT” but not “10% WT BMT”.
    1. J. J. Fuster et al., Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 355, 842-847 (2017).
    2. G. Li et al., Oxidized low-density lip...

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    Competing Interests: None declared.

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