Development

Heal our breaking hearts

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Science  03 Mar 2017:
Vol. 355, Issue 6328, pp. 921
DOI: 10.1126/science.355.6328.921-a

New evidence sheds light on regeneration in human heart tissue.

PHOTO: ROGER J. BICK & BRIAN J. POINDEXTER/UT-HOUSTON MEDICAL SCHOOL/SCIENCE SOURCE

Myocardial infarction (heart attack) causes irreversible damage to the heart, leaving the survivor with reduced cardiac output and lowering their quality of life. Some animals, such as the zebrafish and the neonatal mouse, have a regenerative capacity, but until now, we have not been able to elucidate any regenerative capability in the adult human heart. Voges et al. have grown immature human cardiac organoids that display an innate ability to regenerate after injury. Unlike in adult tissue, these organoids do not form fibrotic scars and can recover functionally. The organoids provide the first insight into human cardiac regeneration and are a step toward finding a source for cellular therapy after cardiac damage.

Development 10.1242/dev.143966 (2017).

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