Contents
Vol 355, Issue 6329
Special Issue
SYNTHETIC YEAST GENOME
Introduction to special issue
Research Articles
Contents
This Week in Science
Editorial
Editors' Choice
Multimedia
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Trump targets environmental science for cuts
Funding for research programs at EPA and NOAA could be slashed in 2018 budget request.
- Blackouts cast Australia's green energy in dim light
South Australia has led the nation in effort to meet Paris climate commitments.
- At 10, Europe's ‘excellence’ fund ponders changes
The European Research Council has earned a reputation for quality—and for being risk averse.
- Chile's glacial lakes pose newly recognized flood threat
Team will develop early warning system for dangerous outburst floods.
- Data Check: Federal share of basic research hits new low
Spike in drug company spending pushes government share below 50%.
Feature
- Making waves
Penny Chisholm has established a once-obscure marine microbe as a key to ocean ecosystems and climate.
- Hubble trouble
How a recharged debate over the expansion of the universe could lead to new physics.
- A cosmic controversy
Two methods come to different conclusions about the Hubble constant.
Working Life
Letters
Books et al.
- Matters of life and death
When the end arrives, should we upgrade or shut down?
- Sea change
A policy-focused history probes the factors driving the decline of global fisheries
Policy Forum
- Policy reforms to update chemical safety testing
TSCA reform empowers EPA to use modernized safety testing in the United States
- Challenges of S&T system reform in China
Despite promising reforms, autonomy is unclear
Perspectives
- It's whom you know that counts
Hometown ties help Chinese scientists get ahead
- Metamaterials for perpetual cooling at large scales
A glass-polymer film can cool structures by radiating heat, even under direct sunlight
- Yeast genome, by design
Scientists are inching closer to generating a synthetic eukaryotic cell
- Time for nonaddictive relief of pain
Greater insight into the biology of pain will likely identify potential drug targets
- Beyond trial and error for zeolite catalysts
Designed zeolites that mimic reaction transition states are highly active and selective catalysts
Reports
- “Ab initio” synthesis of zeolites for preestablished catalytic reactions
Organic molecules for directing structure formation in zeolites mimic the transition states of a desired catalytic reaction.
- Bone-like crack resistance in hierarchical metastable nanolaminate steels
A multiphase nanolaminate microstructured steel shows greatly improved fatigue resistance.
- Photonic doping of epsilon-near-zero media
Photonic doping enables design of materials with enhanced electromagnetic response.
- Scalable-manufactured randomized glass-polymer hybrid metamaterial for daytime radiative cooling
A polymer film with embedded microspheres and a thin backing film of silver achieves daytime radiative cooling.
- Large, valley-exclusive Bloch-Siegert shift in monolayer WS2
Infrared pump-probe spectroscopy is used to measure coherent light-matter interactions in tungsten disulfide.
- The geologic history of seawater pH
Ocean pH has risen steadily since the Archean.
- Molecular and neural basis of contagious itch behavior in mice
Suprachiasmatic neural circuits control contagious itching.
- A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
An isoprenoid released by Plasmodium-infected red blood cells has several functions in enhancing parasite transmission.
- Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
Nucleosome compaction by PRC1 is likely necessary for maintaining gene repression during development.
About The Cover

COVER Illustration of a hypothetical yeast genome structure model encompassing all synthetic chromosomes (gold) completed to date (white, native chromosomes). One-third of the chromosomes in the yeast genome have now been designed and synthesized by the Synthetic Yeast Genome Project (Sc2.0). A three-dimensional model of the chromosomes was generated with the Hi-C method. An "envelope" (thick tube shapes) represents the population of chromosome-interacting molecules; translucent tips reveal a 30-nanometer fiber modeled inside. See page 1038. For the story behind the cover and introductory spread images, see eaan1126
Experimental data: RSG Group/Institut Pasteur; Data processing: J. Mozziconacci, R. Koszul, and J. D. Boeke;
Illustration: Valerie Altounian/Science