Contents
10 March 2017
Vol 355, Issue 6329
Vol 355, Issue 6329
Special Issue
SYNTHETIC YEAST GENOME
Introduction to special issue
Research Articles
Contents
This Week in Science
Editorial
Editors' Choice
Multimedia
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Trump targets environmental science for cuts
Funding for research programs at EPA and NOAA could be slashed in 2018 budget request.
- Blackouts cast Australia's green energy in dim light
South Australia has led the nation in effort to meet Paris climate commitments.
- At 10, Europe's ‘excellence’ fund ponders changes
The European Research Council has earned a reputation for quality—and for being risk averse.
- Chile's glacial lakes pose newly recognized flood threat
Team will develop early warning system for dangerous outburst floods.
- Data Check: Federal share of basic research hits new low
Spike in drug company spending pushes government share below 50%.
Feature
- Making waves
Penny Chisholm has established a once-obscure marine microbe as a key to ocean ecosystems and climate.
- Hubble trouble
How a recharged debate over the expansion of the universe could lead to new physics.
- A cosmic controversy
Two methods come to different conclusions about the Hubble constant.
Working Life
Letters
Books et al.
- Matters of life and death
When the end arrives, should we upgrade or shut down?
- Sea change
A policy-focused history probes the factors driving the decline of global fisheries
Policy Forum
- Policy reforms to update chemical safety testing
TSCA reform empowers EPA to use modernized safety testing in the United States
- Challenges of S&T system reform in China
Despite promising reforms, autonomy is unclear
Perspectives
- It's whom you know that counts
Hometown ties help Chinese scientists get ahead
- Metamaterials for perpetual cooling at large scales
A glass-polymer film can cool structures by radiating heat, even under direct sunlight
- Yeast genome, by design
Scientists are inching closer to generating a synthetic eukaryotic cell
- Time for nonaddictive relief of pain
Greater insight into the biology of pain will likely identify potential drug targets
- Beyond trial and error for zeolite catalysts
Designed zeolites that mimic reaction transition states are highly active and selective catalysts
Reports
- “Ab initio” synthesis of zeolites for preestablished catalytic reactions
Organic molecules for directing structure formation in zeolites mimic the transition states of a desired catalytic reaction.
- Bone-like crack resistance in hierarchical metastable nanolaminate steels
A multiphase nanolaminate microstructured steel shows greatly improved fatigue resistance.
- Photonic doping of epsilon-near-zero media
Photonic doping enables design of materials with enhanced electromagnetic response.
- Scalable-manufactured randomized glass-polymer hybrid metamaterial for daytime radiative cooling
A polymer film with embedded microspheres and a thin backing film of silver achieves daytime radiative cooling.
- Large, valley-exclusive Bloch-Siegert shift in monolayer WS2
Infrared pump-probe spectroscopy is used to measure coherent light-matter interactions in tungsten disulfide.
- The geologic history of seawater pH
Ocean pH has risen steadily since the Archean.
- Molecular and neural basis of contagious itch behavior in mice
Suprachiasmatic neural circuits control contagious itching.
- A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
An isoprenoid released by Plasmodium-infected red blood cells has several functions in enhancing parasite transmission.
- Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
Nucleosome compaction by PRC1 is likely necessary for maintaining gene repression during development.
About The Cover
COVER Illustration of a hypothetical yeast genome structure model encompassing all synthetic chromosomes (gold) completed to date (white, native chromosomes). One-third of the chromosomes in the yeast genome have now been designed and synthesized by the Synthetic Yeast Genome Project (Sc2.0). A three-dimensional model of the chromosomes was generated with the Hi-C method. An "envelope" (thick tube shapes) represents the population of chromosome-interacting molecules; translucent tips reveal a 30-nanometer fiber modeled inside. See page 1038. For the story behind the cover and introductory spread images, see eaan1126
Experimental data: RSG Group/Institut Pasteur; Data processing: J. Mozziconacci, R. Koszul, and J. D. Boeke;
Illustration: Valerie Altounian/Science