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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

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Science  17 Mar 2017:
Vol. 355, Issue 6330, pp. 1206-1211
DOI: 10.1126/science.aag1006

Article Information

vol. 355 no. 6330 1206-1211

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History: 
  • Received for publication May 14, 2016
  • Accepted for publication February 20, 2017

Author Information

  1. Nicolas Blondiaux1,*,
  2. Martin Moune1,*,
  3. Matthieu Desroses2,3,*,
  4. Rosangela Frita1,*,
  5. Marion Flipo2,
  6. Vanessa Mathys4,
  7. Karine Soetaert4,
  8. Mehdi Kiass4,
  9. Vincent Delorme1,5,
  10. Kamel Djaout1,
  11. Vincent Trebosc6,7,
  12. Christian Kemmer6,
  13. René Wintjens8,
  14. Alexandre Wohlkönig9,10,
  15. Rudy Antoine1,
  16. Ludovic Huot1,
  17. David Hot1,
  18. Mireia Coscolla11,12,
  19. Julia Feldmann11,12,
  20. Sebastien Gagneux11,12,
  21. Camille Locht1,
  22. Priscille Brodin1,
  23. Marc Gitzinger6,
  24. Benoit Déprez2,,
  25. Nicolas Willand2,*,,
  26. Alain R. Baulard1,*,
  1. 1Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204-CIIL–Center for Infection and Immunity of Lille, F-59000 Lille, France.
  2. 2Université Lille, Inserm, Institut Pasteur de Lille, U1177–Drugs and Molecules for Living Systems, F-59000 Lille, France.
  3. 3Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  4. 4National Reference Center for Tuberculosis and Mycobacteria, Bacterial Diseases Service, Operational Direction Communicable and Infectious Diseases, Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium.
  5. 5Tuberculosis Research Laboratory, Institut Pasteur Korea, South Korea.
  6. 6Bioversys AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  7. 7Biozentrum, University of Basel, Basel, Switzerland.
  8. 8Laboratoire des Biopolymères et des Nanomatériaux Supramoléculaires, Université Libre de Bruxelles, Brussels, Belgium.
  9. 9VIB Center for Structural Biology, VIB, Pleinlaan 2, 1050 Brussels, Belgium.
  10. 10Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium.
  11. 11Swiss Tropical and Public Health Institute, Basel, Switzerland.
  12. 12University of Basel, Basel, Switzerland.
  1. Corresponding author. Email: benoit.deprez{at}univ-lille2.fr (B.D.); nicolas.willand{at}univ-lille2.fr (N.W.); alain.baulard{at}inserm.fr (A.R.B.)
  1. * These authors contributed equally to this work.

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Mar 20171088414482310
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May 2017963190299
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