CANCER GENOMICS

Effects of the tumor microenvironment

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Science  31 Mar 2017:
Vol. 355, Issue 6332, pp. 1386-1388
DOI: 10.1126/science.355.6332.1386-l

Glioma brain tumors that carry mutant copies of the IDH gene can be subdivided into two major classes. However, the development of and differences between these two classes are not well characterized. Venteicher et al. coupled bulk sequencing and publicly available data with single-cell RNA sequencing data on glioma patient tissue samples. They identified a common lineage program that is shared between glioma subtypes. This suggests that the observed differences between the two glioma classes originate from lineage-specific genetic changes and the tumor microenvironment.

Science, this issue p. eaai8478

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