Research Article

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

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Science  07 Apr 2017:
Vol. 356, Issue 6333, pp. 44-50
DOI: 10.1126/science.aah5298

Article Information

vol. 356 no. 6333 44-50

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History: 
  • Received for publication July 9, 2016
  • Accepted for publication February 22, 2017

Author Information

  1. Romain Bouziat1,2,*,
  2. Reinhard Hinterleitner1,2,*,
  3. Judy J. Brown3,4,*,
  4. Jennifer E. Stencel-Baerenwald3,4,
  5. Mine Ikizler4,5,
  6. Toufic Mayassi1,2,
  7. Marlies Meisel1,2,
  8. Sangman M. Kim1,2,
  9. Valentina Discepolo1,6,
  10. Andrea J. Pruijssers4,5,
  11. Jordan D. Ernest1,2,
  12. Jason A. Iskarpatyoti4,5,
  13. Léa M. M. Costes1,7,
  14. Ian Lawrence1,2,
  15. Brad A. Palanski8,
  16. Mukund Varma9,10,
  17. Matthew A. Zurenski1,2,
  18. Solomiia Khomandiak4,5,
  19. Nicole McAllister3,4,
  20. Pavithra Aravamudhan4,5,
  21. Karl W. Boehme4,5,
  22. Fengling Hu1,
  23. Janneke N. Samsom7,
  24. Hans-Christian Reinecker9,
  25. Sonia S. Kupfer1,11,
  26. Stefano Guandalini11,12,
  27. Carol E. Semrad1,11,
  28. Valérie Abadie13,
  29. Chaitan Khosla8,14,15,
  30. Luis B. Barreiro16,
  31. Ramnik J. Xavier9,10,17,
  32. Aylwin Ng9,10,
  33. Terence S. Dermody3,4,5,18,19,,
  34. Bana Jabri1,2,11,12,20,
  1. 1Department of Medicine, University of Chicago, Chicago, IL, USA.
  2. 2Committee on Immunology, University of Chicago, Chicago, IL, USA.
  3. 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  4. 4Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  5. 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  6. 6Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, and CeInGe–Biotecnologie Avanzate, Naples, Italy.
  7. 7Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, Netherlands.
  8. 8Department of Chemistry, Stanford University, Stanford, CA, USA.
  9. 9Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  10. 10Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  11. 11University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
  12. 12Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.
  13. 13Department of Microbiology, Infectiology, and Immunology, University of Montreal, and the Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montreal, Quebec, Canada.
  14. 14Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
  15. 15Stanford ChEM-H, Stanford University, Stanford, California, USA.
  16. 16Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
  17. 17Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  18. 18Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  19. 19Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  20. 20Department of Pathology, University of Chicago, Chicago, IL, USA.
  1. Corresponding author. Email: bjabri{at}bsd.uchicago.edu (B.J.); terence.dermody{at}chp.edu (T.S.D.)
  1. * These authors contributed equally to this work.

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