Biomaterials

Setting up a recruiting office

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Science  21 Apr 2017:
Vol. 356, Issue 6335, pp. 281-282
DOI: 10.1126/science.356.6335.281-f

The successful growth of large tissues requires the formation of a vascular system to ensure the proper supply of nutrients to the growing cells. One route to angiogenesis in the growing tissue is through the delivery of growth factors such as VEGF, but clinically this method has limitations. An alternative is to harness proangiogenic cells, such as blood-derived CD133+ cells, also known as circulating angiogenic cells (CACs). Parlato et al. used a cell invasion assay to optimize a hydrogel designed to recruit CACs over a period of 24 hours. Although hydrogel degradability and hydrogel stiffness—two known variables often connected with cell behavior—were found to be important in attracting CACs, a key third factor was the presentation of a gradient of stromal derived factor 1.

Acta Biomat. 10.1016/j.actbio.2017.03.048 (2017).

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