Editors' ChoiceBiotechnology

Menstrual cycle on a chip

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Science  28 Apr 2017:
Vol. 356, Issue 6336, pp. 393-394
DOI: 10.1126/science.356.6336.393-d

The female reproductive system is dynamic and complex. Various tissues secrete and respond to hormones to coordinate the 28-day menstrual cycle. This normal physiology has been difficult to study, but Xiao et al. have replicated the reproductive tract in a microfluidic device that they call EVATAR. The tissue culture-based model supports growth and function of ovary, fallopian tube, uterus, cervix, and liver for up to 100 days. Via interconnected modules, the cultured tissues respond to signals produced by each of the other organ cultures. This tool will provide researchers with exciting opportunities to perform pharmacological and toxicology studies on a physiologically relevant model of the human reproductive system.

Nat. Commun. 10.1038/ncomms14584 (2017).

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