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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

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Science  28 Apr 2017:
Vol. 356, Issue 6336, eaal1641
DOI: 10.1126/science.aal1641

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vol. 356 no. 6336

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    Author Information

    1. Michael J. McConnell1,*,,
    2. John V. Moran2,3,*,,
    3. Alexej Abyzov4,
    4. Schahram Akbarian5,
    5. Taejeong Bae4,
    6. Isidro Cortes-Ciriano6,
    7. Jennifer A. Erwin7,
    8. Liana Fasching8,
    9. Diane A. Flasch2,
    10. Donald Freed9,10,
    11. Javier Ganz11,12,
    12. Andrew E. Jaffe13,
    13. Kenneth Y. Kwan2,14,
    14. Minseok Kwon6,
    15. Michael A. Lodato11,12,
    16. Ryan E. Mills2,15,
    17. Apua C. M. Paquola7,
    18. Rachel E. Rodin11,12,
    19. Chaggai Rosenbluh16,
    20. Nenad Sestan17,
    21. Maxwell A. Sherman6,
    22. Joo Heon Shin13,
    23. Saera Song18,19,
    24. Richard E. Straub13,
    25. Jeremy Thorpe9,10,
    26. Daniel R. Weinberger13,20,21,
    27. Alexander E. Urban22,
    28. Bo Zhou22,
    29. Fred H. Gage7,
    30. Thomas Lehner23,
    31. Geetha Senthil23,
    32. Christopher A. Walsh11,12,
    33. Andrew Chess16,
    34. Eric Courchesne24,
    35. Joseph G. Gleeson18,19,
    36. Jeffrey M. Kidd2,15,
    37. Peter J. Park6,
    38. Jonathan Pevsner9,10,
    39. Flora M. Vaccarino8,25,
    40. Brain Somatic Mosaicism Network
    1. Corresponding author. Email: mikemc{at}virginia.edu (M.J.M.); moranj{at}umich.edu (J.V.M.)
      1. 1Department of Biochemistry and Molecular Genetics, Department of Neuroscience, Center for Brain Immunology and Glia, Children’s Health Research Center, and Center for Public Health Genomics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
      2. 2Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA.
      3. 3Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
      4. 4Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, 200 1st Street S.W., Rochester, MN 55905, USA.
      5. 5Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, 1470 Madison Avenue, New York, NY 10029, USA.
      6. 6Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA.
      7. 7The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
      8. 8Child Study Center, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
      9. 9Department of Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205.
      10. 10Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
      11. 11Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children’s Hospital, 3 Blackfan Circle, Boston, MA 02115, USA.
      12. 12Departments of Neurology and Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
      13. 13Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA.
      14. 14Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
      15. 15Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
      16. 16Department of Cell, Developmental and Regenerative Biology, Department of Genetics and Genomic Sciences, Department of Neuroscience, Friedman Brain Institute, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
      17. 17Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
      18. 18Howard Hughes Medical Institute, Laboratory of Pediatric Brain Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10065.
      19. 19Rady Institute of Genomic Medicine, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093, USA.
      20. 20Departments of Psychiatry and Behavioral Sciences and Neuroscience, 600 North Wolfe Street, Baltimore, MD 21287, USA.
      21. 21McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, 733 North Broadway, Baltimore, MD 21230, USA.
      22. 22Department of Psychiatry and Behavioral Sciences and Department of Genetics, Stanford University School of Medicine, 3165 Porter Drive, Palo Alto, CA, 94304, USA.
      23. 23Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Rockville, MD 20852, USA.
      24. 24Autism Center of Excellence, Department of Neuroscience, School of Medicine, University of California San Diego, 8110 La Jolla Shores Drive, La Jolla, CA 92037, USA.
      25. 25Department of Neuroscience, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
      1. * These authors contributed equally to this work.

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