PerspectiveImmunology

Inflammation by way of macrophage metabolism

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Science  05 May 2017:
Vol. 356, Issue 6337, pp. 488-489
DOI: 10.1126/science.aan2691

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Summary

Although inflammation is an essential component of immunity, an excessive response can lead to tissue damage and autoimmune pathologies. In most cases, this is avoided with parallel, integrated regulatory responses that allow healing to commence. A central mediator of this regulatory response is the cytokine interleukin-10 (IL-10). IL-10 is particularly important in mucosal tissues, such as the intestine, where it limits macrophage proinflammatory functions. On page 513 of this issue, Ip et al. (1) report that IL-10 alters macrophage function by promoting the clearance of damaged mitochondria and modulating cellular metabolism to limit inflammation.