Editors' ChoiceARTHRITIS

Targeting senescence to combat osteoarthritis

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Science  12 May 2017:
Vol. 356, Issue 6338, pp. 595-596
DOI: 10.1126/science.356.6338.595-b

During senescence, cells remain in a state of growth arrest. Accumulation of similar nonfunctional cells has been linked to chronic inflammatory diseases and degenerative disorders. Inflammation after joint injury is a common sequela. Jeon et al. sought to understand whether senescence was involved in the development of osteoarthritis by using a model of anterior cruciate ligament surgery. Senescent cells assembled in the traumatized knee joint and triggered development of osteoarthritis and cartilage erosion in mice. By injecting a drug that caused the specific removal of these cells, the arthritis symptoms were alleviated, and cartilage regeneration and recovery were improved.

Nat. Med. 10.1038/nm.4324 (2017).

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