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X-ray Bragg coherent diffractive imaging (BCDI) provides an opportunity to connect the nanoscale world of crystalline lattice defects with the meso- and macroscale world of emergent materials behaviors. On page 739 of this issue, Yau et al. (1) demonstrate that BCDI measurements that are sensitive to individual lattice defects can be carried out on micrometer-scale crystalline grains in complex environments. Crystal defect motions and other structural changes can be tracked. Extending these measurements and combining them with existing and developing mesoscale probes will enable the connection of dynamics on vastly different length scales.