Specific repair by discerning macrophages

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Science  09 Jun 2017:
Vol. 356, Issue 6342, pp. 1014
DOI: 10.1126/science.aan6782

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During the inflammatory response to infection or injury, macrophages are deployed to clear pathogens, dead cells, and debris. But macrophages also play a central role in subsequent tissue repair. On pages 1076 and 1072 of this issue, Minutti et al. (1) and Bosurgi et al. (2), respectively, expand our understanding of the plasticity of macrophages by demonstrating that these cells integrate signals from specific cytokines and from local “organ-specific” cues, or from sensing dying cells, before activating tissue-repair programs.