Research Article

History of winning remodels thalamo-PFC circuit to reinforce social dominance

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Science  14 Jul 2017:
Vol. 357, Issue 6347, pp. 162-168
DOI: 10.1126/science.aak9726

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The brain circuits of a winner

Social dominance in mice depends on their history of winning in social contests. Zhou et al. found that this effect is mediated by neuronal projections from the thalamus to a brain region called the dorsomedial prefrontal cortex. Selective manipulation of synapses driven by this input revealed a causal relationship between circuit activity and mental effort–based dominance behavior. Thus, synapses in this pathway store the memory of previous winning or losing history.

Science, this issue p. 162