Technical Comments

Response to Comment on “Molecular and neural basis of contagious itch behavior in mice”

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Science  14 Jul 2017:
Vol. 357, Issue 6347, eaan5000
DOI: 10.1126/science.aan5000

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Liljencrantz et al. report the failure of observing contagious itch behavior using mice injected with histamine as the demonstrators. Analysis of their results shows that the histamine model is limited by inadequate frequency and duration of scratching bouts required for contagious itch test. To streamline the contagious itch test, the screen paradigm is highly recommended.

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