PerspectiveMaterials Science

Directing reconfigurable DNA nanoarrays

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Science  28 Jul 2017:
Vol. 357, Issue 6349, pp. 352-353
DOI: 10.1126/science.aao0599

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The ability to faithfully pass information in a cascaded and controllable fashion has worked wonders for civilization and biology (see the figure). In the molecular engineering enterprise, researchers have craved a similar level of control over information flow within a network at nanometer-to-micrometer scale. On page 371 of this issue, Song et al. have used DNA, a readily available biopolymer with well-established structure and association rules, to construct finite-sized nanoarrays that transmit information from one side to the other in the form of structural transformation (1). This marks an important step toward programming nanoscale motions because it provides a generalizable way to propagate a local structural change across long distances along designated pathways.