PerspectiveGenome Biology

The genome—seeing it clearly now

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Science  28 Jul 2017:
Vol. 357, Issue 6349, pp. 354-355
DOI: 10.1126/science.aao1893

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It is a curious fact that in many fields of science, central questions that one might assume to have been answered decades ago remain perennially unresolved. In genome biology, one such cornerstone problem has been how DNA is organized in an intact cell nucleus. This conundrum is an important and intriguing one because the human genome is over 2 m in length and yet it is packed into a cellular compartment that is merely about 10 µm in diameter. On page 370 of this issue, Ou et al. (1) now take a major step toward answering this foundational question.