Science Webinar Series

Webinar | Humanized mouse models in checkpoint inhibitor development

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Science  18 Aug 2017:
Vol. 357, Issue 6352, pp. 721
DOI: 10.1126/science.357.6352.721-b

Summary

Humanized tumor xenograft mouse models are powerful experimental systems for studying in vivo interactions between human immune cells and human tumors. These models are generated by engrafting both human hematopoietic stem cells and human tumor tissue into immunodeficient mice, such as the NOD/SCID gamma (NSG) strain. In recent years, humanized tumor xenograft mouse models have been integrated into checkpoint inhibitor development programs at many pharmaceutical and biotechnology companies as an indispensable part of the drug development process. As these models have improved, they have been shown to support higher levels of human myeloid-derived cells and regulatory T cells, and have been used successfully in recent studies of anti-PD1 drugs in lung, breast, bladder, and melanoma. Join our experts to hear about the latest research developments utilizing these cutting-edge models.