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The organoid architect

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Science  25 Aug 2017:
Vol. 357, Issue 6353, pp. 746-749
DOI: 10.1126/science.357.6353.746

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Summary

Hans Clevers, the head of the Hubrecht Laboratory in Utrecht, the Netherlands, has pioneered the development of organoids, miniature versions of human organs that are transforming science and medicine. Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other human organs that can be used to model disease or to serve as test beds for drugs. For example, organoids grown from the guts of individual cystic fibrosis patients are used to predict their response to drugs. Researchers have also created organoids from tumors to mimic cancer, and they’re introducing mutations into organoids grown from healthy tissue to study how cancer arises.