Finding a new purpose for old drugs

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Science  01 Sep 2017:
Vol. 357, Issue 6354, pp. 869-870
DOI: 10.1126/science.aao2992

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The history of Parkinson's disease (PD) therapeutics might be said to typify much of the history of clinical medicine in general. On page 891 of this issue, Mittal et al. (1), true to that tradition, provide an intriguing, unexpected, and potentially highly impactful observation that will likely form the basis of clinical practice in PD patients long before we have a true grasp on the mechanism of action (MOA).