Research Article

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

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Science  01 Sep 2017:
Vol. 357, Issue 6354, pp. 891-898
DOI: 10.1126/science.aaf3934

Article Information

vol. 357 no. 6354 891-898

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History: 
  • Received for publication February 12, 2016
  • Resubmitted February 13, 2017
  • Accepted for publication June 23, 2017

Author Information

  1. Shuchi Mittal1,2,3,
  2. Kjetil Bjørnevik4,5,
  3. Doo Soon Im6,
  4. Adrian Flierl7,
  5. Xianjun Dong1,2,3,
  6. Joseph J. Locascio1,8,
  7. Kristine M. Abo1,
  8. Elizabeth Long1,
  9. Ming Jin2,3,
  10. Bing Xu9,
  11. Yang K. Xiang9,
  12. Jean-Christophe Rochet10,
  13. Anders Engeland4,11,
  14. Patrizia Rizzu12,
  15. Peter Heutink12,
  16. Tim Bartels2,3,
  17. Dennis J. Selkoe2,3,
  18. Barbara J. Caldarone3,13,
  19. Marcie A. Glicksman13,
  20. Vikram Khurana2,3,14,
  21. Birgitt Schüle7,
  22. David S. Park6,
  23. Trond Riise4,5,
  24. Clemens R. Scherzer1,2,3,*
  1. 1Neurogenomics Laboratory and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  2. 2Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  4. 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  5. 5The Norwegian Multiple Sclerosis Competence Center, Department of Neurology, Haukeland University Hospital, Norway.
  6. 6Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  7. 7The Parkinson’s Institute and Clinical Center, Sunnyvale, CA 94085, USA.
  8. 8Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  9. 9Department of Pharmacology, University of California at Davis, Davis, CA 95616, USA.
  10. 10Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
  11. 11Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Oslo, Norway.
  12. 12German Center for Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany.
  13. 13Harvard NeuroDiscovery Center, Harvard Medical School, Boston, MA 02115, USA.
  14. 14Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  1. *Corresponding author. Email: cscherzer{at}rics.bwh.harvard.edu

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Sep 20172041319373331
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Feb 2018963203419
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