Research Article

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

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Science  08 Sep 2017:
Vol. 357, Issue 6355, pp. 1014-1021
DOI: 10.1126/science.aaj2155

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Metabolic programming of tissue APCs

Antigen-presenting cells (APCs) are scattered throughout the body in lymphoid organs and at the portals of pathogen entry, where they act as sentinels of the immune system. Sinclair et al. demonstrate that APCs at different sites have distinctive metabolic signatures and that the development and function of these cells are determined not only by their transcriptional program, but also by their metabolic state (see the Perspective by Wiesner and Klein). The authors identified a central role for mTOR in mediating the metabolic adaptation of such tissue-resident APCs by influencing the immunological character of allergic inflammation. Thus, tissues endow resident APCs with distinctive metabolic characteristics that control APC development and function.

Science, this issue p. 1014; see also p. 973