Research Article

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

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Science  08 Sep 2017:
Vol. 357, Issue 6355, pp. 1014-1021
DOI: 10.1126/science.aaj2155

Article Information

vol. 357 no. 6355 1014-1021

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  • Received for publication September 14, 2016
  • Resubmitted March 29, 2017
  • Accepted for publication June 22, 2017

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Author Information

  1. Charles Sinclair1,*,,
  2. Gayathri Bommakanti1,*,
  3. Luiz Gardinassi2,
  4. Jens Loebbermann1,
  5. Matthew Joseph Johnson1,3,
  6. Paul Hakimpour1,
  7. Thomas Hagan1,
  8. Lydia Benitez1,
  9. Andrei Todor2,
  10. Deepa Machiah4,
  11. Timothy Oriss5,
  12. Anuradha Ray5,
  13. Steven Bosinger6,
  14. Rajesh Ravindran1,,
  15. Shuzhao Li2,
  16. Bali Pulendran1,7,8,§
  1. 1Emory Vaccine Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
  2. 2Department of Medicine, Emory University, Atlanta, GA 30329, USA.
  3. 3Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
  4. 4Yerkes Molecular Pathology Core Laboratory, Yerkes National Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
  5. 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Immunology, University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center (UPMC), University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  6. 6Primate Genomics Core, Yerkes National Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
  7. 7Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
  8. 8Institute for Immunity, Transplantation and Infection, Department of Pathology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  1. §Corresponding author. Email: bpulend{at}; bpulend{at}
  1. * These authors contributed equally to this work.

  • Present address: AstraZeneca, Cancer Research UK (CRUK) Cambridge Institute, Li Ka Shing Center, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

  • Present address: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.


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