Biomaterials

Ways to patch a broken heart

See allHide authors and affiliations

Science  15 Sep 2017:
Vol. 357, Issue 6356, pp. 1109-1110
DOI: 10.1126/science.357.6356.1109-d

Minimizing how invasive a surgical procedure is can benefit the patient, and the same could be true for the delivery of transient patches to help repair damaged tissues. Montgomery et al. designed optimal scaffolds from biodegradable poly[octamethylene maleate (anhydride) citrate] that were confined in bioreactors in their extended shape while seeded with cells. Patches as large as a square centimeter could then be compressed and delivered through an orifice a millimeter wide to repair rat hearts, where the residual stress from the injection process causes the scaffold to return to its original shape, but without damaging the cells. Further tests showed the successful delivery of patches to porcine epicardium, aorta, and liver.

Nat. Mat. 10.1038/nmat4956 (2017).

Navigate This Article