RNA Biology

MicroRNA processing (phase) separated

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Science  22 Sep 2017:
Vol. 357, Issue 6357, pp. 1251-1252
DOI: 10.1126/science.357.6357.1251-f

Paraspeckles are ribonucleoprotein structures inside mammalian cell nuclei. Despite their high abundance in multiple tissues and cell types, their cellular function is not completely clear. Jiang et al. show that paraspeckles enhance global microRNA maturation. RNA and protein components of paraspeckles recruit the microRNA precursors and processing machinery. This enrichment seems to help achieve the high concentrations required for efficient microRNA processing. Whether the compartmentalization reported here represents polymer condensation (phase separation) warrants future investigation.

Nat. Struct. Mol. Biol. 10.1038/nsmb.3455 (2017).

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