In DepthReproducibility

Sloppy reporting on animal studies proves hard to change

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Science  29 Sep 2017:
Vol. 357, Issue 6358, pp. 1337-1338
DOI: 10.1126/science.357.6358.1337

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In 2010, the U.K. National Centre for the Replacement, Refinement & Reduction of Animals in Research developed guidelines to improve reporting on animal experiments. Many papers about in vivo research lack crucial details, such as the strain of mice used, their sex and age, and whether animals were randomly assigned to control and treatment groups. The ARRIVE guidelines—short for Animal Research: Reporting of In Vivo Experiments—have since been supported by more than 1000 journals, yet many scientists still seem unaware of the guidelines or are ignoring them. Researchers, journal editors, and funders are currently discussing ways of accelerating ARRIVE's implementation; new studies offer some clues about how to do that.