PerspectiveBiochemistry

The molecular basis of Alzheimer's plaques

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Science  06 Oct 2017:
Vol. 358, Issue 6359, pp. 45-46
DOI: 10.1126/science.aap8002

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  • Better tools desired for quantitation of insoluble and rigid salts
    • Qiuyun Liu, Professor, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
    • Other Contributors:
      • Zhenlang Chen, Researcher, Shanghai Links Med-technology Co., Ltd, Shanghai, China.
      • Hongyu Zhong, student, Sheffield Medical School, University of Sheffield, Sheffield, UK
      • Zi-Wei Ye, Postdoctoral, Department of Microbiology, The University of Hong Kong, Hong Kong

    Oxalate forms insoluble salts with numerous metal ions which are harmful to cells (1-2). Compounds with similar structures to oxalate, such as ethanol, acetic acid could extend lifespan after moderate intake (3-4). Glyoxylate is widely used in skin care products and could remove age-related wrinkles. Some heart diseases may be caused by the presence of oxalate (5-6). Alzheimer’s disease might be also resulted from the buildup of insoluble and rigid salts (7). However, oxalate eluded efforts by scientists in previous studies, which might be attributed to the insolubility and rigid nature of the oxalate salts and other salts. Better tools are desirable to quantitate and visualize these salts.

    Zhenlang Chen, 2,5 Hongyu Zhong, 3,5 Zi-Wei Ye, 4,5 Qiuyun Liu1*
    1 Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, Biomedical Center, State Key Laboratory of Biocontrol, Lab of Microbial Metabolic Engineering and Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
    2 Shanghai Links Med-technology Co., Ltd, ROOM 1321 Bd No.3, No. 235 Rd Yuan He, Baoshan District, Shanghai, China.
    3 Department of Infection, Immunity & Cardiovascular Disease, Sheffield Medical School, University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
    4 Department of Microbiology, The University of Hong Kong, Hong Kong, China.
    5 Equal contributions.

    *Correspondenc...

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    Competing Interests: None declared.