Converting MOFs into amination catalysts

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Science  20 Oct 2017:
Vol. 358, Issue 6361, pp. 304-305
DOI: 10.1126/science.aap8004

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Amines are extensively used in chemicals, pharmaceuticals, and materials (1). Much effort has been devoted to catalytic reductive amination for the synthesis of amines, but the development of cost-effective catalysts with high activity and selectivity remains an important goal for synthetic chemists (2). On page 326 of this issue, Jagadeesh et al. (3) report a general synthesis of amines, including primary, secondary, tertiary, and N-methylamines (>140 examples), as well as 10 existing drug molecules, by way of the reductive amination of carbonyl compounds by using a highly effective cobalt nanoparticle (Co NP) catalyst with a well-defined structure derived from the pyrolysis of a metal-organic framework (MOF) compound.