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D4 dopamine receptor high-resolution structures enable the discovery of selective agonists

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Science  20 Oct 2017:
Vol. 358, Issue 6361, pp. 381-386
DOI: 10.1126/science.aan5468

Article Information

vol. 358 no. 6361 381-386

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History: 
  • Received for publication April 28, 2017
  • Accepted for publication September 7, 2017

Author Information

  1. Sheng Wang1,*,,
  2. Daniel Wacker1,*,,
  3. Anat Levit2,*,
  4. Tao Che1,
  5. Robin M. Betz3,4,5,6,
  6. John D. McCorvy1,
  7. A. J. Venkatakrishnan3,4,5,
  8. Xi-Ping Huang1,
  9. Ron O. Dror3,4,5,6,
  10. Brian K. Shoichet2,,
  11. Bryan L. Roth1,7,8,
  1. 1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA.
  2. 2Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158-2280, USA.
  3. 3Department of Computer Science, Stanford University, CA 94305, USA.
  4. 4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  5. 5Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.
  6. 6Biophysics Program, Stanford University, Stanford, CA 94305, USA.
  7. 7Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.
  8. 8National Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA.
  1. Corresponding author. Email: shengunc{at}email.unc.edu (S.W.); dwacker{at}email.unc.edu (D.W.); bshoichet{at}gmail.com (B.K.S.); bryan_roth{at}med.unc.edu (B.L.R.)
  1. * These authors contributed equally to this work.

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