Dendritic Cells

Lysosomal calcium in dendritic cell migration

See allHide authors and affiliations

Science  03 Nov 2017:
Vol. 358, Issue 6363, pp. 604-605
DOI: 10.1126/science.358.6363.604-i

Activation of dendritic cells (DCs) by stimuli such as bacterial sensing promotes DC maturation. In contrast to random migratory patterns of immature DCs, mature DCs migrate in a continuous and directional manner. Bretou et al. examined the role of lysosomes in regulating mature DC migration. Release of lysosomal calcium connects DC activation with directional migration. Deletion of a lysosomal calcium channel impaired directional DC migration and DC chemotaxis to lymph nodes. Thus, release of lysosomal calcium links stimulus sensing with DC migration.

Sci. Immunol. 2, eaak9573 (2017).

Navigate This Article