ReportMaterials Science

Self-assembled three-dimensional chiral colloidal architecture

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Science  03 Nov 2017:
Vol. 358, Issue 6363, pp. 633-636
DOI: 10.1126/science.aan5404

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Precise chiral colloidal assembly

A challenge for particle assembly is to bring different colloids together in a controlled and uniform way that goes beyond making lattice structures. Ben Zion et al. used DNA origami to pattern colloidal particles and assemble them into clusters with controlled chirality and composition. DNA belts wrapped flat along the curvature of a colloidal particle in an L-like shape. This meant that other achiral colloidal particles, each furnished with a specific complementary DNA belt, could only attach in one orientation.

Science, this issue p. 633

Abstract

Although stereochemistry has been a central focus of the molecular sciences since Pasteur, its province has previously been restricted to the nanometric scale. We have programmed the self-assembly of micron-sized colloidal clusters with structural information stemming from a nanometric arrangement. This was done by combining DNA nanotechnology with colloidal science. Using the functional flexibility of DNA origami in conjunction with the structural rigidity of colloidal particles, we demonstrate the parallel self-assembly of three-dimensional microconstructs, evincing highly specific geometry that includes control over position, dihedral angles, and cluster chirality.

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