Controlling cellular calcium concentration

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Science  10 Nov 2017:
Vol. 358, Issue 6364, pp. 759
DOI: 10.1126/science.358.6364.759-a

Immunostaining of basigin (red), a key regulator of Ca2+ transport, in the cerebellum

CREDIT: N. SCHMIDT ET AL., NEURON 10.1016/J.NEURON.2017.09.038 (2017)

Calcium-based signaling is used in many cellular and neuronal processes to initiate rapid responses to extracellular signals. Cells therefore maintain tight control over intracellular Ca2+ levels, using a variety of channels and pumps. Plasma membrane Ca2+-ATPases (PMCAs) are present in virtually all types of cells and transport Ca2+ to the extracellular space. Schmidt et al. used high-resolution proteomics, electrophysiology, biochemistry, and immunocytochemistry on wild-type and knockout cells and animals to study PMCA-interacting proteins. They identified two proteins, neuroplastin and basigin, as previously unrecognized auxiliary subunits of PMCAs. Both neuroplastin and basigin are essential for the stability of the heterotetrameric PMCA complexes and for efficient control of PMCA-mediated Ca2+ removal under resting conditions and after activity-initiated Ca2+ influx.

Neuron 10.1016/j.neuron.2017.09.038 (2017).

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