Coactivator starts and stalls

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Science  24 Nov 2017:
Vol. 358, Issue 6366, pp. 1016-1017
DOI: 10.1126/science.358.6366.1016-d

In embryonic development and growth control, the histone acetyltransferase p300/CBP (CBP) serves as a transcriptional coactivator with hundreds of different partner transcription factors. By examining the role of CBP in fruitfly cells, Boija et al. have extended its functional repertoire in regulating gene expression. Promoters cobound with CBP and GAGA factor were among the most highly expressed and displayed the most highly paused polymerase (Pol) II. CBP kept Pol II in the stalled position but also aided subsequent transcription elongation through release at the first downstream nucleosome. In addition, CBP and the general transcription factor TFIIB recruited Pol II to the promoter. These CBP activities clarify the mechanism by which the ubiquitous CBP factor does its job as transcriptional coactivator for many cell processes.

Mol. Cell 10.1016/j.molcel.2017.09.031 (2017).

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