PerspectiveMolecular Biology

Enhancing the RNA engineering toolkit

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Science  24 Nov 2017:
Vol. 358, Issue 6366, pp. 996-997
DOI: 10.1126/science.aar2400

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RNA plays important and diverse roles in biology, but tools to study and engineer it are limited. Abudayyeh et al. (1) and, on page 1019 of this issue, Cox et al. (2) have developed effective programmable tools using newly discovered CRISPR-associated 13 (Cas13) enzymes to achieve precise RNA targeting, cleavage, tracking, and editing in mammalian cells.