PerspectiveCANCER BIOLOGY

Bone voyage—Osteoblasts remotely control tumors

See allHide authors and affiliations

Science  01 Dec 2017:
Vol. 358, Issue 6367, pp. 1127-1128
DOI: 10.1126/science.aar2640

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Cancer is a systemic disease. Tumor growth and malignant progression rely not only on the intrinsic aberrant genetic and epigenetic makeup of tumor cells but also on the tumor-induced systemic factors that affect cells in the primary tumor as well as distant microenvironments (1). Notably, bone marrow-derived cells (BMDCs) have been shown to contribute to primary tumor progression by promoting hallmark processes such as inflammation, immunosuppression, vasculogenesis, and extracellular matrix remodeling. BMDCs are also involved in establishing tumor-permissive microenvironments that form before the arrival of disseminated tumor cells at future metastatic sites (known as premetastatic niches) and promote metastatic outgrowth (25). In addition to the direct effects of tumor-secreted factors on BMDC recruitment to tumors, on page eaal5081 of this issue Engblom et al. (6) report that osteoblasts, which reside in the bone, can be remotely activated by secreted factors from lung adenocarcinoma, which in turn mobilize a specific subset of BMDCs—neutrophils—to foster tumor growth.