Essays on Science and SocietyTranslational Medicine

Metabolic markers as cancer clues

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Science  08 Dec 2017:
Vol. 358, Issue 6368, pp. 1265
DOI: 10.1126/science.aar2001


The study of cancer metabolism began almost a century ago when Otto Warburg noted that cancerous tissues metabolize glucose differently from their normal counterparts (1). It has since become widely understood that cancer cells, and proliferating cells more broadly, carry out a metabolic program that favors the accumulation of new biomass components by synthesizing amino acids, lipids, and nucleotides necessary for the generation of daughter cells (2).