Health and Medicine

Taking a direct route to the brain

See allHide authors and affiliations

Science  08 Dec 2017:
Vol. 358, Issue 6368, pp. 1266-1267
DOI: 10.1126/science.358.6368.1266-i

Hematopoietic stem and progenitor cells (HSPCs) rapidly generated myeloid and microglial cells in diseased mice when injected directly into the brain. To circumvent the blood-brain barrier, Capotondo et al. injected human HSPCs into cerebral lateral ventricles in a mouse model of neurodegenerative disease. The approach resulted in the rapid and robust production of HSPC-derived myeloid and microglia cells at the site where they are needed most.

Sci. Adv. 10.1126/sciadv.1701211 (2017).

Navigate This Article