Signal Transduction

Unconventional thyroid hormone signals

See allHide authors and affiliations

Science  05 Jan 2018:
Vol. 359, Issue 6371, pp. 44
DOI: 10.1126/science.359.6371.44-b

Thyroid hormone canonically signals through thyroid hormone receptors to enhance transcription of target genes. There is also evidence that thyroid hormone can activate nontranscriptional signaling mechanisms. To sort out the relative importance of canonical and noncanonical signaling, Hones et al. generated mice in which thyroid hormone receptors were altered to prevent DNA binding and transcriptional effects (but noncanonical signaling remained) and compared thyroid hormone action in these animals with that in wild-type mice or mice lacking thyroid hormone receptors entirely. They found that in vivo, several physiological actions of thyroid hormone—including regulation of body temperature, glucose and triglyceride concentrations in the blood, and heart rate—all appear to be mediated by noncanonical or nontranscriptional mechanisms.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1706801115 (2017).

Navigate This Article