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CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi

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Science  12 Jan 2018:
Vol. 359, Issue 6372, pp. 232-236
DOI: 10.1126/science.aao1503

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Phagocytes patrol intestinal fungi

Maintaining a healthy balance of gut bacteria can promote good health. Leonardi et al. show that fungi can also interact with gut immune cells to maintain intestinal well-being. CX3CR1+ mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms were detected in Crohn's disease patients that were unable to produce antibodies against multiple fungal species. Thus, commensal fungi may be as important as bacteria in maintaining gut health, and antifungal therapy could hold promise for treating intestinal inflammation.

Science, this issue p. 232