GENE REGULATION

Regulation through the core

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Science  26 Jan 2018:
Vol. 359, Issue 6374, pp. 408-409
DOI: 10.1126/science.359.6374.408-d

Enhancers play a pivotal role in gene regulation. These elements can be localized far from the promoter, with looped sequences bringing them together to effect regulated expression. Batut and Gingeras used high-throughput transcription start site mapping and expression patterns to examine promoter activity during early development in five different Drosophila species. During early, intermediate, and late embryogenesis, specific core promoters are active, with each core promoter class associated with specific sets of transcription factors. Coarse- and fine-grained developmental regulation are proposed relative to core promoter and enhancer activity, respectively. Genome-wide analysis of long noncoding RNAs (lncRNAs) reveals 3973 promoters, most of which are unannotated, driving expression during embryo development and showing deep conservation of lncRNA promoters. This work shows that enhancers are not the only sequence regulating transcription; core promoters are also key.

eLife 10.7554/eLife.29005 (2017).

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