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Science  26 Jan 2018:
Vol. 359, Issue 6374, pp. 474
DOI: 10.1126/science.359.6374.474

Flow Cytometer

An evolution of the CytoFLEX platform, the new CytoFLEX LX Flow Cytometer is available with up to six lasers and 21-color detection. It offers great performance and exquisite sensitivity for small-particle analysis in a benchtop analyzer, an extensive set of repositionable bandpass filters, flexibility to upgrade by adding additional parameters, and intuitive software to facilitate multicolor analysis. The fully activated instrument includes three fluorescent channels from the 488-nm (blue) laser, three from the 638-nm (red) laser, five from the 405-nm (violet) laser, five from the 561-nm (yellow) laser, three from the 375-nm (near-UV) laser, and two from the 808-nm (infrared) laser. Go ahead—push the boundaries of flow cytometry with the CytoFLEX LX.

Autophagy Reagents

Sino Biological offers autophagy-related (Atg) molecules and proteins. Autophagy was the subject of the 2016 Nobel Prize in Physiology or Medicine—it controls important physiological functions through an internal recycling program, eliminating invading intracellular bacteria and viruses, contributing to embryo development and cell differentiation, and functioning in signaling pathways and therapy targets in cancer. It plays a role in innate and adaptive immunity, programmed cell death, neurodegeneration, and aging. Examples of autophagy reagents offered by Sino Biological include Atg molecules and MARCH2, a newly discovered negative regulator of cell autophagy. MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation, and PIK3CA-AKT-mTOR signaling.

Secondary Antibodies

Invitrogen Alexa Fluor Plus secondary antibodies represent an advancement in fluorescent-conjugate technology, designed to provide brighter signals, enhanced sensitivity, and minimal cross-reactivity in a variety of applications. Take your cell imaging and Western blotting results to another level—these antibodies offer up to 4x higher signal-to-noise ratio than others on the market; superior detection and visualization of low-abundance targets in challenging samples; improved sensitivity and range of linear detection for more detail; and a unique, proprietary dye chemistry you can't get from anyone else. Make your low-abundance targets visible, spend less time optimizing, and make every one of your precious samples count.

Protein Aggregate Separation and Characterization System

Postnova Analytics' AF2000 MALS is a temperature-controlled, asymmetrical flow field-flow fractionation (AF4), multiangle light scattering (MALS) system, developed to provide unmatched separation, characterization, and fractionation of biopharmaceutical proteins. The system replaces the liquid chromatography column with a proprietary separation-channel technology that retains molecules based only on size and by the influence of crossflow as a separation force. Because of its unique design and the absence of any stationary phase, separation is achieved without exerting shear forces and stress on proteins and aggregates. Incorporating MALS and AF4, the AF2000 MALS operates over a very broad molar-mass and particle-size range. The system can achieve separations with higher resolution, reproducibility, and recovery than previously possible.

CRISPR Guide RNA

A shortfall of many CRISPR-Cas9 gene-editing experiments is that the guide RNA, which directs the Cas9 nuclease to cut at a specific genomic DNA target site, may cause a double-strand break without triggering functional knockout of the protein. We use a powerful algorithm in the genome-wide design of our Edit-R Predesigned Synthetic crRNAs and Lentiviral sgRNAs, for editing of human, mouse, and rat genes. Now you only need to do a gene search to get either synthetic CRISPR RNA (crRNA) or lentiviral single-guide RNA (sgRNA) products for functional target-gene knockout. By assessing functional phenotypes for thousands of designs, then validating our design rules in other assay systems, we have established rules for determining target sites that are more likely to result in efficient cleavage and functional knockout with high specificity.

RNA Methylation Analysis

Expand your understanding of RNA methylation with EpiGentek's complete suite of RNA methylation products. Recent data strongly suggest that m6A and 5-mC RNA methylation affects regulation of various biological processes such as RNA stability and mRNA translation, and that abnormal RNA methylation contributes to the etiology of human diseases. From directly quantifying the "fifth RNA base," N6-methyladenosine (m6A), to measuring global 5-methylcytosine (5-mC) RNA and more, our kits make it easy for you to determine how RNA methylation influences your research projects. We offer one m6A RNA kit [EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)] and three 5-mC RNA kits: MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric); EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina); and Methylamp RNA Bisulfite Conversion Kit. 

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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