Immunology

High caloric intake induces inflammation

See allHide authors and affiliations

Science  02 Feb 2018:
Vol. 359, Issue 6375, pp. 531-532
DOI: 10.1126/science.359.6375.531-b

The consumption of high-calorie diets has become prevalent in industrialized nations and is associated with increased body mass, inflammation, and resulting pathologies. What are the underlying mechanisms connecting diets of high-energy, processed food to inflammation? Christ et al. show that mice fed on a high-calorie Western diet developed systemic inflammation and functionally reprogrammed granulocyte monocyte precursor cells. After a standard chow diet was restored to the animals, inflammation persisted, indicating that components in the Western diet induced innate immune memory. This study identifies possible targets for preventing diet-induced inflammation.

Cell 172, 162 (2018).

Navigate This Article