Review

Programming gene and engineered-cell therapies with synthetic biology

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Science  09 Feb 2018:
Vol. 359, Issue 6376, eaad1067
DOI: 10.1126/science.aad1067

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Toward programmed therapeutics

Advances in synthetic biology are enabling the development of new gene and cell therapies. Kitada et al. review recent successes in areas such as cancer immunotherapy and stem cell therapy, point out the limitations of current approaches, and describe prospects for using synthetic biology to overcome these challenges. Broader adoption of these therapies requires precise, context-specific control over cellular behavior. Gene circuits can be built to give sophisticated control over cellular behaviors so that therapeutic functions can, for example, be programmed to activate in response to disease biomarkers.

Science, this issue p. eaad1067