Report

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

See allHide authors and affiliations

Science  23 Feb 2018:
Vol. 359, Issue 6378, pp. 920-926
DOI: 10.1126/science.aao2774

Article Information

vol. 359 no. 6378 920-926

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 4, 2017
  • Resubmitted October 26, 2017
  • Accepted for publication January 11, 2018

Author Information

  1. Georgios Vlachogiannis1,
  2. Somaieh Hedayat1,
  3. Alexandra Vatsiou2,
  4. Yann Jamin3,
  5. Javier Fernández-Mateos1,2,
  6. Khurum Khan1,4,
  7. Andrea Lampis1,
  8. Katherine Eason1,
  9. Ian Huntingford1,
  10. Rosemary Burke5,
  11. Mihaela Rata3,
  12. Dow-Mu Koh3,6,
  13. Nina Tunariu3,6,
  14. David Collins3,
  15. Sanna Hulkki-Wilson1,
  16. Chanthirika Ragulan1,
  17. Inmaculada Spiteri2,
  18. Sing Yu Moorcraft4,
  19. Ian Chau4,
  20. Sheela Rao4,
  21. David Watkins4,
  22. Nicos Fotiadis6,
  23. Maria Bali3,6,
  24. Mahnaz Darvish-Damavandi1,
  25. Hazel Lote1,4,
  26. Zakaria Eltahir1,
  27. Elizabeth C. Smyth4,
  28. Ruwaida Begum4,
  29. Paul A. Clarke5,
  30. Jens C. Hahne1,
  31. Mitchell Dowsett7,
  32. Johann de Bono8,
  33. Paul Workman5,
  34. Anguraj Sadanandam1,
  35. Matteo Fassan9,
  36. Owen J. Sansom10,
  37. Suzanne Eccles5,
  38. Naureen Starling4,
  39. Chiara Braconi4,5,
  40. Andrea Sottoriva2,
  41. Simon P. Robinson3,
  42. David Cunningham4,
  43. Nicola Valeri1,4,*
  1. 1Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
  2. 2Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
  3. 3Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, London, UK.
  4. 4Department of Medicine, The Royal Marsden NHS Trust, London, UK.
  5. 5Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
  6. 6Department of Radiology, The Royal Marsden NHS Trust, London, UK.
  7. 7Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital NHS Trust, London, UK.
  8. 8Division of Clinical Studies, The Institute of Cancer Research, London, UK.
  9. 9Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy.
  10. 10Cancer Research UK Beatson Institute, Glasgow, UK.
  1. *Corresponding author. Email: nicola.valeri{at}icr.ac.uk

Altmetric

Article usage

Article usage: February 2018 to December 2018

AbstractFullPdf
Feb 20182140221884244
Mar 2018878816252827
Apr 20183271520869
May 20182320424711
Jun 20181781291576
Jul 20181141310394
Aug 2018591597355
Sep 2018758538300
Oct 2018783633402
Nov 2018639609308
Dec 2018486292129